Periodontal Disease and CV Disease: Just Friends? 1

Demonstrating once again that association and causation should not be confused, the American Heart Association today published a scientific statement in Circulation asserting that there is no convincing evidence showing that periodontal disease causes cardiovascular (CV) disease or that treating periodontal disease will reduce CV disease. The statement does not rule out the possibility that periodontal disease can cause CV disease, and even notes that a cause and effect relationship is “biologically plausible,” but it concludes that statements that claim “a causative association…   or claim that therapeutic interventions may be useful on the basis of that assumption are unwarranted.”

“There’s a lot of confusion out there,” said Peter Lockhart, co-chair of the statement writing group and professor and chair of oral medicine at the Carolinas Medical Center in Charlotte, N.C., in an AHA press release. “The message sent out by some in healthcare professions that heart attack and stroke are directly linked to gum disease, can distort the facts, alarm patients and perhaps shift the focus on prevention away from well known risk factors for these diseases.”

In recent years there has been an explosion of studies exploring the relationship of PD disease and CV disease, many looking at inflammation as a common factor underlying both diseases. However, sorting out the precise nature of the relationship is difficult because both diseases share common risk factors, including cigarette smoking, age, and diabetes.

Here is the press release from the AHA:

No proof that gum disease causes heart disease or stroke

Statement Highlights:

  • There is no convincing evidence that proves gum disease causes heart disease or stroke, or treating gum disease reduces the risk of those diseases.
  • Gum and heart disease share common risk factors, including smoking, age and diabetes, which is possibly why the diseases often occur in the same person.
EMBARGOED UNTIL 3 pm CT/4 pm ET, Wednesday, April 18
DALLAS, April 18, 2012 — Despite popular belief, gum disease hasn’t been proven to cause atherosclerotic heart disease or stroke, and treating gum disease hasn’t been proven to prevent heart disease or stroke, according to a new scientific statement published inCirculation, an American Heart Association journal
 
Keeping teeth and gums healthy is important for your overall health. However, an American Heart Association expert committee — made up of cardiologists, dentists and infectious diseases specialists — found no conclusive scientific evidence that gum disease, also known as periodontal disease, causes or increases the rates of cardiovascular diseases. Current data don’t indicate whether regular brushing and flossing or treatment of gum disease can cut the incidence of atherosclerosis, the narrowing of the arteries that can cause heart attacks and strokes.
Observational studies have noted associations between gum disease and cardiovascular disease, but the 500 journal articles and studies reviewed by the committee didn’t confirm a causative link.
“There’s a lot of confusion out there,” said Peter Lockhart, D.D.S., co-chair of the statement writing group and professor and chair of oral medicine at the Carolinas Medical Center in Charlotte, N.C. “The message sent out by some in healthcare professions that heart attack and stroke are directly linked to gum disease, can distort the facts, alarm patients and perhaps shift the focus on prevention away from well known risk factors for these diseases.”
Gum disease and cardiovascular disease both produce markers of inflammation External link such as C-reactive protein, and share other common risk factors External link  as well, including cigarette smoking, age and diabetes mellitus External link. These common factors may help explain why diseases of the blood vessels and mouth occur in tandem. Although several studies appeared to show a stronger relationship between these diseases, in those studies researchers didn’t account for the risk factors common to both diseases.
“Much of the literature is conflicting,” Lockhart said, “but if there was a strong causative link, we would likely know that by now.”
A large, long-term study would be needed to prove if dental disease causes heart disease and stroke, he said.
Such a study isn’t likely to be done in the near future, and it’s most important to let patients know “what we know now, and what we don’t know,” Lockhart said.
For more than a century, doctors have proposed that infected gums lead to systemic problems like heart disease, and we know that mouth bacteria frequently enter the blood stream during dental procedures and during naturally occurring events such as tooth brushing.
“We already know that some people are less proactive about their cardiovascular health than others. Individuals who do not pay attention to the very powerful and well proven risk factors, like smoking, diabetes or high blood pressure, may not pay close attention to their oral health either” Lockhart said.
Statements that imply a cause and effect relationship between periodontal disease and cardiovascular disease, or claim that dental treatment may prevent heart attack or stroke are “unwarranted,” at this time, the statement authors said.
The American Dental Association Council on Scientific Affairs and World Heart Federation endorsed the statement.
The statement’s writing group was co-chaired by Ann F. Bolger, M.D. Other co-authors are Panos N. Papapanou, D.D.S., Ph.D.; Olusegun Osinbowale, M.D.; Maurizo Trevisan, M.D.; Matthew E. Levison, M.D.; Kathryn A. Taubert, Ph.D.; Jane W. Newburger, M.D., M.P.H; Heather L. Gornik, M.D., M.H.S.; Michael H. Gewitz, M.D.; Walter R. Wilson, M.D.; Sidney C. Smith Jr., M.D.; and Larry M. Baddour, M.D. Author disclosures are on the manuscript.
Learn more about how a healthy lifestyle External link and healthy eating External link are important steps toward good health. Take these free risk assessment quizzes External link and find your personal risk of heart attack, high blood pressure and diabetes. Visit the American Stroke Association External link site for comprehensive info on stroke.
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One comment

  1. I look at a lot of the studies, as non-Cardiologist, and am shocked by the lack of rigor and flagrant conflict of interest. This was a doozy! People that take poor care of themselves will have a number of health issues and potential correlation is, no doubt, available at every turn. Time to understand illness is systemic and that an obese person will probably have heart disease, diabetes and poor tooth hygiene. So, what’s new?

    Tooth plaque isn’t a cause, it is a symptom. Get some exercise, eat no sugar and low fat and you will see reduced plaque in your arteries and mouth. That’s the correlation.

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